Table 2. The ROC analysis in stratified five-fold cross-validation for evaluating the accuracy of the combined diagnostic model*.
| Discrimination between PD and healthy subjects |
Discrimination between Early PD and healthy subjects |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC | 95% CI of AUC |
Cut-off Point | Sensitivity | Specificity | AUC | 95% CI of AUC |
Cut-off Point | Sensitivity | Specificity | ||||
| Lower Bound | Upper Bound | Lower Bound | Upper Bound | ||||||||||
| Fold 1 | 1.000 | 1.000 | 1.000 | 0.466 | 100.0% | 100.0% | Fold 1 | 1.000 | 1.000 | 1.000 | 0.457 | 100.0% | 100.0% |
| Fold 2 | 0.969 | 0.876 | 1.000 | 0.729 | 87.5% | 100.0% | Fold 2 | 0.938 | 0.762 | 1.000 | 0.601 | 75.0% | 100.0% |
| Fold 3 | 1.000 | 1.000 | 1.000 | 0.493 | 100.0% | 100.0% | Fold 3 | 1.000 | 1.000 | 1.000 | 0.468 | 100.0% | 100.0% |
| Fold 4 | 1.000 | 1.000 | 1.000 | 0.498 | 100.0% | 100.0% | Fold 4 | 1.000 | 1.000 | 1.000 | 0.492 | 100.0% | 100.0% |
| Fold 5 | 0.969 | 0.876 | 1.000 | 0.495 | 87.5% | 100.0% | Fold 5 | 0.938 | 0.762 | 1.000 | 0.490 | 75.0% | 100.0% |
| Mean | 0.988 | 0.967 | 1.000 | 0.536 | 95.0% | 100.0% | Mean | 0.975 | 0.933 | 1.000 | 0.502 | 90.0% | 100.0% |
*In every fold analysis within stratified five-fold cross-validation, FA-SNAv, CBF-PFCAv and FA-PWMAv were consistently selected into the combined diagnostic model.