Figure 3. Conserved sequence signatures in Plasmodium and other known and putative eukaryotic pantothenate kinases.

Pantothenate kinase fumble domain sequence organization. Residues that were described to be conserved between plant and human enzymes are shaded in black. Similar residues found at these positions are shaded in dark grey (hydrophobic: I, L, M, V; small: A, C, G, S, T; Negative: D, E; Positive: K, H, R; aromatic: F, W, Y). Other conserved residues according to Muscle multiple alignment are highlighted in light grey. Four highly conserved PanK motifs TGGGxYKF, A/VNIGSGI/VS, iGGGTxxGLxxLI/L and LDIGGS/TLiKLaY that are present in human and plant PanKs are also present in Plasmodium PanK1²⁴, while Plasmodium PanK2 harbors the highly conserved PanK motifs DxxVxDxYGx and GLxxxxxASxFG.