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. 2016 Sep 15;4:e2461. doi: 10.7717/peerj.2461

Figure 3. Overexpression of debcl enhances the α-synuclein-induced phenotypes.

Figure 3

(A) Directed overexpression of debcl in the DA neurons severely decreases longevity whereas its inhibition shows an improvement in lifespan. Genotypes are UAS-α-synuclein Ddc-Gal4/UAS-lacZ; UAS-α-synuclein Ddc-Gal4/UAS-Debcl-RNAi; and UAS-α-synuclein Ddc-Gal4/UAS-Debcl. Longevity is shown as percent survival (P < 0.01, determined by log-rank and n ≥ 200). (B) The co-expression of debcl in the α-synuclein model of PD enhanced the age-dependent loss in climbing ability. The directed inhibition of debcl in the DA neurons improved the climbing ability over time compared to the control. The genotypes are UAS-α-synuclein; Ddc-Gal4/UAS-lacZ, UAS-α-synuclein; Ddc-Gal4/UAS-debcl-RNAi, and UAS-α-synuclein; Ddc-Gal4/UAS-debcl. Analysis of the climbing curves and significance was determined by comparing the 95% confidence intervals. Error bars indicate the SEM and n = 50.