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Representative micrographs of a gastric adenocarcinoma showing heterogeneous erbB2 immunohistochemical expression. In this paradigmatic example of HER2 heterogeneity in gastric cancer, the tumor showed the coexistence of 2+ (A), 3+ (B, C), and negative areas (C), with the former immunohistochemical pattern involving the majority of the tumor cells. Original magnification × 200.
