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. 2016 Sep 6;2016:1286510. doi: 10.1155/2016/1286510

Figure 10.

Figure 10

TYR, DCT, and AIM1 upstream regions and associated candidate enhancer modules. (a) The upstream region from the python tyrosinase gene (TYR) contains a cluster of pigmentation associated transcription factor binding sites located between position 1 and position 200. This cluster includes binding sites for POU3F2, USF-1, LEF-1, and FOXD3. A second cluster occurs between position 410 and position 640 that contains sites for FOXD3, LEF-1, USF-1, and POU3F2. The third cluster is located from position 1210 to position 1410 and contains binding sites for CREB, MITF, POU3F2, and USF-1. (b) The upstream region of python dopachrome tautomerase (DCT) contains a cluster of binding sites from position 675 to position 800 that include LEF-1, POU3F2, MITF, and FOXD3. A second cluster occurs from position 800 to position 1000 which includes binding sites for transcription factors FOXD3, POU3F2, USF-1, LEF-1, and MITF. The third cluster contains binding sites for LEF-1, MITF, USF-1, POU3F2, and FOXD3. (c) The upstream region from Absent In Melanoma 1 (AIM1) (Figure 10(c)) contains a cluster of transcription factor binding sites between position 725 and position 925 for POU3F2, USF-1, MITF, FOXD3, and LEF-1. A second cluster of sites beginning at position 950 and ending at position 1150 contains binding sites for POU3F2 and FOXD3. A third cluster of binding sites beginning at position 1200 and ending at position 1500 has binding sites for USF-1, POU3F2, and LEF-1.