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. 2016 Sep 6;2016:1286510. doi: 10.1155/2016/1286510

Figure 11.

Figure 11

MLANA, RAB27A, and MC1R upstream regions and associated candidate enhancer modules. (a) The upstream region from melan-A (MLANA) contains a cluster of binding sites beginning at position 275 and ending at position 475 which include recognition sites for LEF-1, POU3F2, USF-1, and FOX3D. A second cluster of binding sites begins at position 650 and extends to position 850 which contains binding sites for POU3F2, LEF-1, and FOX3D. The third cluster of sites occurs between position 1100 and position 1300 which contains binding sites for FOXD3, POU3F2, and USF-1. (b) The upstream region for RAS oncogene family member 27A (RAB27A) (Figure 11(b)) has a cluster of transcription factor binding sites beginning at position 250 and ending at position 450 which include sites for POU3F2, USF-1, and FOXD3. The second cluster of binding sites begins at position 500 and ends at position 700 which contains sites for POU3F2, USF-1, FOX3D, and LEF-1. The third cluster begins at position 1050 and ends at position 1250 and binds LEF-1, USF-1, CREB, FOX3D, and POU3F2. (c) The upstream region for melanocortin 1 receptor (MC1R) contains a cluster of transcription factor binding sites for USF-1 and POU3F2 between position 150 and position 350. A second cluster begins at position 725 and ends at position 925 with binding sites for USF-1, LEF-1, FOX3D, POU3F2, and MITF. A third cluster of binding sites is located between position 1225 and position 1425 with sites for LEF-1, USF-1, POU3F2, and FOXD3.