Table 2.
Changes of 24-hour urinary protein, urinary 8-iso-PGF2a, and renal Ang II levels in urine 24 h after different treatment.
| Normal | Control | EGCG A | EGCG B | |
|---|---|---|---|---|
| 24-hour urinary protein (mg) | ||||
| Baseline | 1.2 ± 0.3 | 5.8 ± 0.6## | 5.9 ± 0.9## | 5.7 ± 1.1## |
| Week 4 | 1.1 ± 0.7 | 7.5 ± 0.2## | 6.7 ± 0.1##∗∗ | 6.7 ± 0.5##∗∗ |
| Week 8 | 1.3 ± 0.5 | 11.9 ± 1.3## | 8.8 ± 1.0##∗ | 8.6 ± 1.1##∗ |
| Urinary 8-iso-PGF2a (ng/d) | ||||
| Baseline | 38.5 ± 5.3 | 84.6 ± 8.5## | 87.2 ± 11.3## | 86.8 ± 12.1## |
| Week 4 | 39.8 ± 3.6 | 150.4 ± 11.9## | 107.3 ± 12.1##∗∗ | 110.6 ± 9.2##∗∗ |
| Week 8 | 38.7 ± 4.4 | 176.8 ± 10.1## | 138.5 ± 8.3##∗∗ | 126.7 ± 9.5##∗∗ |
| Renal Ang II (ng/L) | ||||
| Baseline | 177.6 ± 20.2 | 238.3 ± 14.2## | 240.5 ± 19.8## | 238.9 ± 16.6## |
| Week 4 | 182.4 ± 12.1 | 346.2 ± 22.7## | 297.5 ± 15.5##∗ | 308.9 ± 7.3##∗ |
| Week 8 | 191.3 ± 23.9 | 405.8 ± 7.2## | 367.4 ± 5.4##∗∗ | 383.7 ± 9.6##∗ |
Note: normal, C57BLKS/J normal nontreated mice; control, C57BLKS/J db/db nontreated mice; EGCG A, db/db mice treated with EGCG of 50 mg/kg/d; EGCG B, db/db mice treated with EGCG of 100 mg/kg/d; urinary 8-iso-PGF2a, urinary 8-iso-prostaglandin F2α; Ang II: the renal angiotensin II concentration; ## P < 0.01 versus normal; ∗ P < 0.05 and ∗∗ P < 0.01 versus control; values are means ± SEM. At baseline and at week 4, n = 16 in each group; at week 8, n = 8 in each group.