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Pharmacokinetics of Debio1143, means ± standard deviation
| Dose | Day | N | Cmax [mg/l] | Tmax° [h] | T1/2 [h] | AUC0-inf [mg*h/l] |
|---|---|---|---|---|---|---|
| 100 mg | 1 | 8 | 1.2 ± 0.7 | 2.6 | 5.0 ± 1.1 | 6.0 ± 3.5 |
| 5 | 8 | 8.3 ± 0.8 | 2.9 | 13.0 ± 2.9 | 8.5 ± 5.7 | |
|
| ||||||
| 200 mg | 1 | 12 | 3.0 ± 1.8 | 1.5 | 5.6 ± 0.9 | 18 ± 9 |
| 5 | 12 | 2.4 ± 1.3 | 1.5 | 18.0 ± 5.1 | 24 ± 14 | |
|
| ||||||
| 300 mg | 1 | 4 | 4.4 ± 1.7 | 1.2 | 4.9 ± 1.0 | 25 ± 12 |
| 5 | 4 | 2.5 ± 4.0 | 2.0 | 15.9 ± 3.4 | 24 ± 11 | |
|
| ||||||
| 400 mg | 1 | 4 | 9.5 ± 4.5 | 1.0 | 5.9 ± 1.4 | 55 ± 20 |
| 5 | 4 | 5.6 ± 1.8 | 2.5 | 25.5 ± 3.7 | 72 ± 20 | |
Median
