FIG. 2.

RT models of WT and mutant Y188C/L228I. The RT models of WT and mutant are shown in ribbon diagram. Subunits of p66 and p51 are colored as blue and green, respectively (a). The residues at 228, 188 (b, c), and K65–K70 (d, e) in p66 subunit are highlighted. Their atoms are labeled in ball-and-stick format. The hydrogen bond between L228 and Y188 is shown in red dotted line (b). The DNA/RNA hybrid is shown in tube format in pink, while the NNRTI NVP is shown in CPK format (a). The figures were produced using DS Visualizer (Accelrys). Color images available online at www.liebertpub.com/aid