FIG. 4.

RT models of WT and mutant A139V/Y232H. The models of WT and mutant are shown in ribbon diagram. Subunits of p66 and p51 are colored as blue and green, respectively. The residues at 232 and its vicinal sites in p66 subunit, as well as A139 and S134 in p51 subunit, are highlighted. Their atoms are labeled in ball-and-stick format. Y232 is colored in yellow. The hydrogen bond between A(V)139 and S134 is shown in red dotted line. The DNA/RNA hybrid is shown in tube format in pink, and the NNRTI NVP is shown in CPK format. The figures were produced using DS Visualizer (Accelrys). Color images available online at www.liebertpub.com/aid