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. 2016 Sep 20;4:58. doi: 10.1186/s40425-016-0162-9

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Maximum intensity projection images of two whole-body 18 F-FDG PET/CT studies. Panel a shows the PETCT from 11/20/15, early in the course of immunotherapy. Panel b shows the PET/CT from 2/11/16, after completion of induction ipilimumab/nivolumab. Arrows indicate the increased metabolic glucose consumption in bilateral inguinal, iliac, axillary lymph nodes as well as the spleen, highly suggestive of immune activation