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. 2016 Sep 19;35:147. doi: 10.1186/s13046-016-0405-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The RFD score is higher in AML and is related to outcome. a Examples of the Gomori staining of reticulin fibers in the BM sections from normal controls and AML patients, which were further divided into CR and refractory groups. Both images are at a magnification of 1000×. b The RFD for the AML-CR (n = 38) and AML-refractory (n = 25) patients compared to the normal controls (n = 59), *** p < 0.001 (c) RFS of AML-CR patients subdivided into high (>1.13 %) and low (≤1.13 %) RFD groups, P = 0.003. d OS of all the AML patients subdivided into high (>3.68 %) and low (≤3.68%) RFD groups, P < 0.001. e-f Scatter plot: RFD vs. blasts in the peripheral blood and the blasts in the BM of primary AML patients using linear regression analysis (P = 0.47 and 0.70 respectively)