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. 2016 Sep 20;14:269. doi: 10.1186/s12967-016-1031-5

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effects of statins on mevalonate pathway in tumor cells. Downstream products in the mevalonate pathway such as geranylgeranyl pyrophosphate (GGPP) and farnesyl pyrophosphate (FPP) are substrates in protein prenylation. By inhibiting the formation of GGPP and FPP, statins exert anti-proliferatic activity in tumor cells