Table 3.
In-vitro screening of traditionally used anti-leishmanial and anti-malarial plants against Leishmania and Plasmodia parasites
| Plant name | Part used | Parasite type | Extract | Concentration (µg/ml) | Inhibition (%) | Citation |
|---|---|---|---|---|---|---|
| Aloe vera | Leaves | Leishmania tropica | Crude methanol | 25 | 15 | [25] |
| 50 | 27 | |||||
| 75 | 43 | |||||
| 100 | 66 | |||||
| Artemisia annua | Leaves | Plasmodium falciparum | Aqueous | 0.095 | 50 | [86] |
| Azadiracha indica | Leaves | Plasmodium falciparum | Ethanol | 2.4 | 50 | [36] |
| 2.5 | 50 | |||||
| Asparagus asiaticus | Roots | Leishmania major | Crude methanol | 25 | 22 | [63] |
| 50 | 34 | |||||
| 250 | 42 | |||||
| 500 | 51 | |||||
| Amphotericin B (Reference drug as a control) |
25 | 50 | ||||
| 50 | 75 | |||||
| 250 | 88 | |||||
| 500 | 100 | |||||
| Citrullus colocynthis | Fruits | Leishmania major | Crude methanol | 25 | 67 | [35] |
| 50 | 71 | |||||
| 250 | 88 | |||||
| 500 | 100 | |||||
| Juniperus excels | Fresh berries | Leishmania major | Crude methanol | 25 | 49 | [37] |
| 50 | 58 | |||||
| 250 | 88 | |||||
| 500 | 97 | |||||
| Melia azedarach | Fruit | Leishmania tropica | Aqueous | 1500 | 55.9 | [86] |
| 2500 | 67.4 | |||||
| 5000 | 80.4 | |||||
| Moringa oleifera | Leaves | Plasmodium falciparum | Acetone | 400 | 59.8 | [31] |
| Nepeta praetervisa | Leaves | Leishmania major | Methanol | 25 | 39 | [62] |
| 50 | 54 | |||||
| 250 | 68 | |||||
| 500 | 78 | |||||
| Peganum harmala | Seeds | Plasmodium falciparum | Ethanol | 12.5 | 91 | [58] |
| 25 | 97.4 | |||||
| 50 | 98.5 | |||||
| 100 | 99.8 | |||||
| Chloroquine | NA | 99.6 | ||||
| Perotis hordeiformis | Leaves | Leishmania major | Methanol | 25 | 47 | [65] |
| 50 | 58 | |||||
| 250 | 70 | |||||
| 500 | 80 | |||||
| Amphotericin B (Reference drug as a control) |
25 | 50 | ||||
| 50 | 75 | |||||
| 250 | 88 | |||||
| 500 | 100 | |||||
| Rhazya stricta | Leaves | Leishmania major | Crude methanol | 25 | 65 | [34] |
| 50 | 70 | |||||
| 250 | 92 | |||||
| 500 | 100 | |||||
| Salvia bucharica | Leaves | Leishmania major | Crude methanol | 25 | 44 | [67] |
| 50 | 40 | |||||
| 250 | 59 | |||||
| 500 | 75 | |||||
| Tamarix aphylla | Barks | Leishmania tropica | Crude methanol | 25 | 20 | [25] |
| 50 | 28 | |||||
| 75 | 54 | |||||
| 100 | 84 | |||||
| Thuspeinanta brahuica | Leaves | Leishmania major | Crude methanol | 25 | 40 | [87] |
| 50 | 58 | |||||
| 75 | 70 | |||||
| 100 | 82 | |||||
| Amphotericin B (Reference drug as a control) | 25 | 50 | ||||
| 50 | 75 | |||||
| 75 | 88 | |||||
| 100 | 100 |