Table 1.
Exosomal components significantly changed after donor cell exposure to ionizing radiation.
Biological source of exosomes | Dose of ionizing radiation | Time from IR to exosome isolation | Changed components in exosomes released from treated cells | Refs. |
---|---|---|---|---|
Human epithelial prostate cell carcinoma (22Rv1) | 4 Gy | 96 h | Increased level of B7-H3 (CD276) | [55] |
Human serum | Radiotherapy treatment | No information | Increased level of HSP72 protein | [56] |
Human glioblastoma multiforme (U87MG) | 4 Gy | 24-48 h | Abnormally increased levels of CTGF mRNA and IGFBP2 protein | [7] |
Human head and neck squamous cell carcinoma (FaDu) | 2 Gy | 18 h | Increased levels of proteins involved in transcription/translation (EIFs, PSMs, RPLs and RPSs), cell cycle/division (chaperones, ubiquitination-related factors and proteasome components) and cell signaling (ARFs, RABs and RASs proteins); Decreased levels of apolipoproteins and immunoglobulins |
[57] |