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. 2016 Jul;23(7):656–663. doi: 10.2174/0929866523666160427105138

Table 1.

Exosomal components significantly changed after donor cell exposure to ionizing radiation.

Biological source of exosomes Dose of ionizing radiation Time from IR to exosome isolation Changed components in exosomes released from treated cells Refs.
Human epithelial prostate cell carcinoma (22Rv1) 4 Gy 96 h Increased level of B7-H3 (CD276) [55]
Human serum Radiotherapy treatment No information Increased level of HSP72 protein [56]
Human glioblastoma multiforme (U87MG) 4 Gy 24-48 h Abnormally increased levels of CTGF mRNA and IGFBP2 protein [7]
Human head and neck squamous cell carcinoma (FaDu) 2 Gy 18 h Increased levels of proteins involved in transcription/translation (EIFs, PSMs, RPLs and RPSs), cell cycle/division (chaperones, ubiquitination-related factors and proteasome components) and cell signaling (ARFs, RABs and RASs proteins);
Decreased levels of apolipoproteins and immunoglobulins
[57]
HHS Vulnerability Disclosure