Table 2.
Examples of RIBEs perpetuated by exosomes in recipient cells.
| Donor cells | Recipient cells |
Dose of ionizing
radiation |
Time from IR to exosome isolation | Bystander effects in recipient cells | Refs. |
|---|---|---|---|---|---|
| Human breast cancer cell line (MCF-7) | MCF-7 | 2 Gy | 4 h | DNA (comet assay) and chromosomal (metaphases analysis) damage after 24 h of incubation | [6] |
| Human keratinocyte cells (HaCaT) | HaCaT | 0.005 Gy; 0.05 Gy ; 0.5 Gy | 1 h | Cell death (the alamarBlue® assay) after 72 h of incubation | [54] |
| Human breast cancer cell line (MCF-7) | MCF-7 | 2 Gy | 4 h | DNA (comet assay) and chromosomal (metaphases analysis damage) after 24 h of incubation up to 20 cell-doublings | [8] |