Figure 2. Cumulative Incidence and Cumulative Burden of Chronic Cardiovascular Health Conditions among Hodgkin Lymphoma Survivors and Community-Controls.

Technical note: The atypical pattern of the 95% confidence limits of survivors' curves is due to application of left-truncation and multiple imputation in the estimation of cumulative incidence and cumulative burden. Furthermore, the atypical pattern of the numbers at risk for cumulative incidence and cumulative burden is due to the following reasons:

Cumulative incidence: For controls, everyone started the at-risk period at birth (age 0). At this beginning of the start of the at-risk period, the number of our community controls at risk is 272 (the total number of our community controls). Until the first censoring, death, or the first occurrence of cardiovascular conditions of interest, the number at risk remains at 272.

For survivors, the start of the at-risk period is 10 years post Hodgkin lymphoma diagnosis or age of 18 years whichever comes later, i.e., the SJLIFE cohort entry. Thus, age at the start of the at-risk period differs across survivors, which led to the number of survivors at risk increasing over age up to about 30 years old and then decreasing. There are a total of 670 survivors and the latest age at the cohort entry was 35 years old. Because some people were censored before age 35, there is no time point at which the number at risk was 670.

Cumulative burden: For cumulative burden, people stay at risk during their length of follow-up. Unlike cumulative incidence which stops the at-risk period at the occurrence of the event of interest, cumulative burden keeps subjects who have events of interest at risk: the two methods are equal in their handling of censoring at the end of follow-up and deaths.