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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: JAMA Neurol. 2016 Jun 1;73(6):721–732. doi: 10.1001/jamaneurol.2016.0580

Figure 3. Association of Total Anticholinergic (AC) Burden Score and Brain Atrophy.

Figure 3

The total AC burden score was significantly associated with both cognition and brain atrophy. Specifically, a higher total AC burden score was associated with poorer performance on the Trail Making Test Part B (TMT-B) (r = 0.137; P = .01, with transient ischemic attack and total number of medications as additional covariates [A]) and greater inferior lateral ventricle (r = 0.126; P = .03 [B]) and lateral ventricle volumes (r = 0.145; P = .01 [C]). Inferior lateral ventricle volume was still significantly associated with the total AC burden score after excluding participants with a total AC burden score of 0 (r = 0.331; P < .001 [E]). The TMT-B score (r = 0.146; P = .06 [D]) and lateral ventricle volume showed nonsignificant trend associations with the total AC burden score after excluding those with a total AC burden score of 0 (r = 0.152; P = .10 [F]).