Table.

Demographic Characteristics and Medical Histories of 402 Participants From the ADNI

Characteristic	Participants, No.		P Value
	AC− (n = 350)	AC+ (n = 52)
Age, mean (SD), y	73.3 (5.8)	73.3 (6.6)	.96
Sex
Male	171	18	.06
Female	179	34
Education, mean (SD), y	16.4 (2.6)	16.1 (2.7)	.40
Handedness
Right	318	50	.20
Left	32	2
APOE ε4 positive, % of participants	28.0	25.0	.65
Non-Hispanic white, % of participants	84.6	94.2	.06
Medications, mean (SD), Total No.	4.2 (2.8)	6.7 (3.1)	<.001
Comorbid conditions, mean (SD), Total No.	1.8 (1.3)	2.2 (1.5)	.03
Transient ischemic attack
No	341	51	.78
Yes	9	1
Myocardial infarction
No	325	51	.15
Yes	25	1
Cardiac surgery
No	330	50	.58
Yes	20	2
Hypertension
No	193	24	.23
Yes	157	28
Hyperlipidemia
No	181	29	.59
Yes	169	23
Diabetes
No	324	49	.67
Yes	26	3
Sleep apnea
No	334	49	.70
Yes	16	3
Other vascular conditions (eg, atrial fibrillation)
No	327	47	.42
Yes	23	5
Anxiety
No	342	47	.01
Yes	8	5
Depression
No	306	37	.002
Yes	44	15
Insomnia
No	338	46	.01
Yes	12	6
ADD or ADHD
No	348	52	.59
Yes	2	0
Other psychiatric condition (eg, posttraumatic stress disorder)
No	348	52	.56
Yes	2	0
Concussion
No	331	48	.51
Yes	19	4

Abbreviations: AC⁺, participant taking anticholinergic medication with medium or high anticholinergic activity; AC⁻, participant not taking anticholinergic medication; ADD, attention-deficit disorder; ADHD, attention-deficit/ hyperactivity disorder; ADNI, Alzheimer’s Disease Neuroimaging Initiative.