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. 2016 Sep 20;6:33856. doi: 10.1038/srep33856

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Copyright © 2016, The Author(s)

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(A–H) Transverse view of H&E staining of mouse thorax sections from E13.5 to E18.5. The transverse sectional profiles of the LOXL3-deficient thoraxes tended to be flat from E14.5 to E18.5 compared with the wild-type thoraxes. Bar: 2 mm. (I,J) Lateral view of Alizarin Red staining of mouse skeletons at E18.5. The side profiles of the LOXL3-deficient thoraxes also exhibited spine and rib deformities. Bar: 2 mm. (K) The thoracic volumes in the Loxl3^−/− mice were also significantly decreased at E18.5. n = 3 in each group, P = 0.013.