Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct;22(10):1535–1549. doi: 10.1261/rna.056101.116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Qiu et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 2. — Characterization of hematopoietic lineage-defining splicing programs. (A) Principal component analysis (PCA) represents the results of regression analysis that identified a splicing program that differentiates between normal hematopoietic cell lineages (Hemo-SP panel). (B) Unsupervised hierarchical clustering of normal hematopoietic cell samples using the 200-event cell lineage-specific panel (Hemo-SP). A code was assigned to each lineage. Unsupervised hierarchical clustering of MDS blood samples with fixed 200-event panel as used. (C) A demonstration tree of hematopoietic lineages. Hematopoietic stem cell (HSC); bone marrow progenitor cells (BMPC); bone marrow (BM); common myeloid progenitor cell (CMP); granulocyte (GC); monocyte (MC); B-lymphocyte (B); T-lymphocyte (T); peripheral blood (PB). As CMP and SC were very well correlated across all events, and each group had limited sample numbers, we combined these two groups together as CMP. (D) Canonical pathways identified by Ingenuity IPA analysis of the hematopoietic lineage-specific panel (Hemo-SP). (E) Segregation of MDS samples from different cell types from healthy controls based on Hemo-SP by PCA.