Figure 5.
BECN1 interactions in the PI3KC3 complex II. All proteins are shown in ribbon, colored as: VPS30, yellow; VPS38, green; VPS15, grey, and VPS34, blue. Protein domains implicated in membrane interaction, the BECN1 BARAD, UVRAG BARA2 and PI3KC3 catalytic domain are labeled. Boxes indicate regions that were enlarged and rotated to demonstrate interactions. Interacting side chains, mutated to the VPS30 sequence from the 4.4 Å poly‐alanine structure, are displayed as sticks.