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. 2016 Feb 24;7(4):333–345. doi: 10.1177/1947603515623991

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Figure 7. — Counter-regulating mechanism on the effects of RBPMS (RNA-binding protein with multiple splicing) on Smad2/3 signaling. The scheme shows that RBPMS is regulated by TGF-β (transforming growth factor-β) signaling by pSmads, that is, negatively regulated by phosphorylated Smad2/3 and positively regulated by phosphorylated Smad1/5/8 and it also shows that RBPMS may be regulating TGF-β signaling by acting as linker molecule that might enhance phosphorylation of Smad2 and Smad3 by forming a complex with TGFBR (TGF-β receptor) and unphosphorylated Smad2/3.