Figure 5. Gene expression changes specific for Runx1 deletion in Eμ-Myc lymphoma cells.

A. Ingenuity Pathway Analysis of the most changed genes (Figure 4) revealed significant enrichment for genes involved in the processes depicted. P-values are shown for top sub-processes in relevant categories. B. Venn diagram showing the overlap of the gene signatures for the significant processes in A. Genes in bold italics show increased expression on loss of Runx1, while the remainder are down-regulated. C. Validation of key target genes contributing to the Runx1 deletion signatures. Fold changes estimated by microarray and RQ-PCR are shown alongside comparable array values for the 30s control cells.