Figure 8. Runx1^null lymphoma cells are tumorigenic but are out-competed by Runx1^fl/fl cells in ascitic fluid and in the blood of in dexamethasone-treated mice.

A. Runx1 excision PCR on genomic DNA from vehicle control (Runx1⁺) or IFNβ-treated (Runx1^null) 3s cell line cells (“input”), and from cells from ascites fluid (upper panel) and tumors in skin (lower panel) derived from 4 mice transplanted IP with each of the input cell types. B. Runx1 excision PCR on genomic DNA of cells derived from blood and spleen of 12 mice comprising 6 mice transplanted intravenously with Runx1⁺(3s+) and 6 with Runx1^null (3s-) cells, and 3 mice from each of these groups treated with dexamethasone or vehicle control as detailed in Materials and Methods.