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. 2016 Mar 30;7(17):23006–23018. doi: 10.18632/oncotarget.8470

Figure 3. Nbn-deficiency promotes psoriasiform dermatitis.

Figure 3

A. Characterization of the psoriasiform dermatitis and inflammatory response using various cell type markers: Krt14, Krt10 and Loricrin; proliferation marker: Pcna (scale bar 20 μm). Immunohistochemistry of P90 NbnEgr2-Cre skins indicates inflammatory response with T-cell marker (Cd3+, scale bar 20 μm), coloration of mast cells (blue) with GIEMSA (scale bar 40 μm) and macrophages (F4/80+). B. P90 NbnEgr2-Cre skins highly expressed typical human psoriasiform dermatitis interleukins Il17c, Il23 and Il33. NbnCtrl (N = 4), NbnEgr2-Cre (N = 4). **** : p < 0.0001, *** : p = 0.0002, ** : p = 0.0077. C. Up-regulation of p-Stat3, p-S6, p-p38 and p-p44 in P90 NbnEgr2-Cre skins. D. γ-H2afx foci in keratinocytes trigger Trp53 stabilization and E. increased Cdkn2a (p16INK4A) and Cdkn1a (p21Cip1/Waf1) expression in P90 NbnEgr2-Cre skins. NbnCtrl (N = 4), NbnEgr2-Cre (N = 4). ****: p < 0.0001.