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A.+B. Significantly enhanced MED8 protein expression was observed in metastases derived from ccRCC. C. MED8 overexpression (z-score > 1.5) is associated with strongly reduced survival in ccRCC patients. D. MED8 knockdown led to significantly reduced proliferation in the ccRCC cell lines A-498 and ACHN. E. Migration was significantly impaired in MED8-deficient cells as compared to scrambled control cells.
