. 2015 Dec 31;7(17):23156–23169. doi: 10.18632/oncotarget.6804

Table 2. Significant associations of SNPs in HRe genes with CRC risk (stratification for colon and rectal cancer is also reported).

Gene SNP	Genotype	^aControls(n = 1442)	All cancer patients				Rectal cancer patients				Colon cancer patients
Gene SNP	Genotype	^aControls(n = 1442)	^aCases (n = 1090)	^bOR	95% CI	P	^aCases (n = 369)	^bOR	95% CI	P	Cases (n = 710)	^bOR	95% CI	P
RAD52	GG	839	610	Ref			213	Ref			395	Ref
rs1051669	GA	505	381	1.05	0.85–1.29	0.65	121	0.96	0.70–1.30	0.78	260	1.09	0.86–1.37	0.49
	AA	70	81	1.68	1.11–2.54	0.01	28	1.39	0.74–2.59	0.31	52	1.78	1.13–2.80	0.01
	GA+AA	575	462	1.12	0.92–1.37	0.25	149	1.01	0.75–1.35	0.97	312	1.17	0.93–1.46	0.18
	GG+GA	1344	991	Ref			334	Ref			655	Ref
	AA	70	81	1.65	1.10–2.50	0.02	28	1.41	0.76–2.61	0.28	52	1.72	1.10–2.69	0.02
RAD52	TT	1045	820	Ref			266	Ref			551	Ref
rs11571475	TC	353	237	0.88	0.70–1.11	0.29	88	1.14	0.82–1.59	0.45	149	0.76	0.58–1.00	0.05
	CC	24	20	0.90	0.41–1.96	0.79	12	2.36	0.97–5.73	0.06	8	0.41	0.14–1.26	0.12
	TC+CC	377	257	0.88	0.70–1.11	0.29	100	1.21	0.88–1.67	0.24	157	0.74	0.57–0.97	0.03
	TT+TC	1398	1057	Ref			354	Ref			700	Ref
	CC	24	20	0.92	0.42–2.01	0.84	12	2.28	0.95–5.52	0.07	8	0.44	0.14–1.34	0.15
RAD52	TT	1024	808	Ref			280	Ref			526	Ref
rs7963551	TG	375	246	0.83	0.66–1.04	0.11	80	0.88	0.64–1.23	0.47	165	0.81	0.63–1.05	0.12
	GG	35	17	0.53	0.26-1.11	0.09	5	0.29	0.08–1.13	0.07	12	0.64	0.29–1.38	0.25
	TG+GG	410	263	0.80	0.64–1.00	0.05	85	0.83	0.60–1.15	0.26	177	0.80	0.62–1.02	0.08
	TT+TG	1400	1054	Ref			360	Ref			691	Ref
	GG	35	17	0.56	0.27–1.16	0.12	5	0.30	0.08–1.16	0.08	12	0.67	0.31–1.46	0.31
MRE11A	TT	610	499	Ref			181	Ref			316	Ref
rs2155209	TC	638	485	0.86	0.70–1.06	0.16	162	0.75	0.56–1.01	0.06	322	0.94	0.75–1.19	0.61
	CC	180	92	0.54	0.38–0.76	0.0004	22	0.32	0.18–0.59	0.0002	70	0.66	0.45–0.96	0.03
	TC+CC	818	577	0.79	0.65–0.96	0.02	184	0.66	0.49–0.87	0.004	392	0.88	0.70–1.09	0.24
	TT+TC	1248	984	Ref			343	Ref			638	Ref
	CC	180	92	0.58	0.42–0.81	0.001	22	0.37	0.21–0.67	0.0009	70	0.68	0.47–0.97	0.03
NBN	TT	1308	1010	Ref			343	Ref			664	Ref
rs14448	TC	107	74	0.67	0.45–1.00	0.05	22	0.41	0.21–0.80	0.01	52	0.78	0.51–1.19	0.24
	CC	0	0	-	–	–	0	–	–	–	0	–	–	–
	TC+CC	107	74	0.67	0.45–1.00	0.05	22	0.41	0.21-0.80	0.01	52	0.78	0.51-1.19	0.24
	TT+TC	1415	1084	Ref			365	Ref			716	Ref
	CC	0	0	–	–	–	0	–	–	–	0	–	–	–

Abbreviations: OR, odds ratio; 95% CI, confidence interval. Significant results in bold.

Numbers may not add up to 100% of available subjects because of genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to two additional rounds of genotyping. Data points that were still not filled after this procedure had been left blank.

Adjusted for sex, age and smoking.

χ² and P-values for the deviation of observed and the numbers expected from the Hardy–Weinberg equilibrium (HWE) considering all controls.