Table 3. Clinical and anamnestic characteristics significantly affecting Overall Survival (OS) and Event Free Survival (EFS) of the CRC patients with complete follow up (Cox regression).

		OS			EFS
		Na	HR (95% CI)	P	HR (95% CI)	P
Sex	Females	427	Ref		Ref
	Males	656	1.54 (1.23–1.92)	0.0001	1.35 (1.09–1.68)	0.006
Age (years)	55 ≤	293	Ref		Ref
	56–62	248	1.43 (1.05–1.95)	0.02	1.41 (1.06–1.87)	0.02
	63–70	294	1.39 (1.04–1.88)	0.03	1.19 (0.90–1.58)	0.22
	> 70	248	2.02 (1.50–2.72)	< 0.0001	1.04 (0.76–1.42)	0.80
Smoking habit*	No	533	Ref		Ref
	Yes	493	1.26 (1.02–1.56)	0.03	1.14 (0.93–1.41)	0.19
pT	1	50	Ref		Ref
	2	166	2.64 (0.94–7.40)	0.06	2.18 (0.85–5.55)	0.10
	3	535	5.84 (2.17–15.71)	0.0005	5.58 (2.30–13.53)	0.0001
	4	136	9.21 (3.36–25.26)	< 0.0001	6.96 (2.80–17.27)	< 0.0001
pN	0	498	Ref		Ref
	1	260	2.17 (1.69–2.79)	< 0.0001	1.87 (1.46–2.41)	< 0.0001
	2	68	3.40 (2.35–4.91)	< 0.0001	3.43 (2.45–4.81)	< 0.0001
pM	0	725	Ref		Ref
	1	177	4.80 (3.83–6.02)	< 0.0001	4.56 (3.68–5.65)	< 0.0001
5FU-based chemotherapy	Yes	411	Ref		Ref
	No	440	1.42 (1.13–1.790)	0.003	0.85 (0.68–1.06)	0.14
Histologic Grade	1	125	Ref		Ref
	2	464	1.84 (1.26–2.69)	0.002	1.42(1.00–2.02)	0.05
	3-4	199	2.35 (1.57–3.53)	< 0.0001	1.88 (1.29–2.76)	0.001
Stage	1	149	Ref		Ref
	2	293	2.14 (1.32–3.48)	0.002	2.47 (1.51–4.05)	0.0003
	3	244	3.75 (2.33–6.03)	< 0.0001	3.87 (2.38–6.31)	< 0.0001
	4	177	11.87 (7.44–18.95)	< 0.0001	11.86 (7.42–18.98)	< 0.0001

^*Ex-smokers included in non-smokers

Abbreviations: HR, hazard ratio; 95% CI, confidence interval. Significant results in bold.

^aNumbers may not add up to 100% of available subjects because of missing information