Table 3. Adverse events at any dose level.

Adverse Event of All Grades	Dose Level of Temsirolimus (mg)/Bevacizumab (mg/kg)/Cetuximab LD/MD (mg/m2)
	5/5/100/75 (n = 3)		5/10/100/75 (n = 16)		12.5/2.5/100/75 (n = 2)		Total (n = 21)
	G1-2	G3-4	G1-2	G3-4	G1-2	G3-4	G1-2	G3-4
Abdominal Pain	0	0	1	0	0	0	1	0
Anemia	3	0	13	1	2	0	18	1
Anorexia	0	0	2	0	2	0	4	0
Dermatitis	1	0	10	0	1	0	12	0
Diarrhea	0	0	1	0	0	0	1	0
Dysuria	0	0	1	0	0	0	1	0
Epistaxis	1	0	2	0	0	0	3	0
Fatigue	2	0	8	0	1	1	11	1
Fever	0	0	1	0	0	0	1	0
Headache	0	0	4	0	1	1	5	1
Hypercholesterolemia	2	0	9	0	0	0	11	0
Hyperglycemia	3	0	8	3	1	0	12	3
Hyperkalemia	1	0	2	1	2	0	5	1
Hypertension	0	0	2	0	0	0	2	0
Hypertriglyceridemia	3	0	11	0	1	0	15	0
Hypokalemia	1	0	4	1	1	0	6	1
Hypophosphatemia	1	0	3	1	0	2	4	3
Elevated AST	3	0	8	1	0	0	11	1
Hyperbilirubinemia	0	0	1	0	0	0	1	0
Renal Insufficiency	1	0	3	0	0	0	4	0
Elevated ALT	2	0	6	0	1	0	9	0
Infection (ear, orbit)	1	0	3	0	0	0	4	0
Leukopenia/Neutropenia	0	1	5	0	1	0	6	1
Mucositis/Glossitis	2	0	8	0	0	1	10	1
Nail Discoloration	0	0	2	0	0	0	2	0
Nausea	1	0	3	0	2	0	6	0
Proteinuria	2	0	11	0	0	0	13	0
Dyspnea with Exertion	0	0	1	0	0	0	1	0
Stomatitis	0	0	2	0	0	0	2	0
Thrombocytopenia	0	0	3	0	2	0	5	0
Fistula	1	0	0	0	0	0	1	0
Hypomagnesemia	1	0	0	0	0	0	1	0
Pneumonitis	1	0	0	0	0	0	1	0
Vomiting	1	0	0	1	2	0	3	1
Oral thrush	0	0	0	0	1	0	1	0
Constipation	0	0	0	0	1	0	1	0
Infusion Reaction	0	0	0	1	0	0	0	1
Stomach leak/rupture	0	0	0	1	0	0	0	1

LD: loading dose; MD: maintenance dose.