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. 2016 Mar 15;7(17):23239–23250. doi: 10.18632/oncotarget.8096

Figure 5. Emetine reduced AML burden in an in vivo xenotransplantation mouse model.

Figure 5

A. Conditioned NSG mice were intravenously (IV) transplanted with HL-60 cells. At day 7, mice were treated daily intraperitoneally (IP) with emetine (1 mg/kg) or vehicle control for 7 days. At day 21, bones were harvested and analyzed. B. Frequency of human CD45 positive cells in bone marrow referred to control (left panel) as assessed by flow cytometry. The right panel shows a representative flow cytometry plot of control- and emetine-treated bone marrow. C. Total number of ex vivo CFUs in control- and emetine-treated mice (left panel). Representative image of control- and emetine-treated colony. Error bars represent SEM. *p < 0.05.