Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Mar 14;7(17):23552–23568. doi: 10.18632/oncotarget.8083

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2016 Mukherjee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

(A, B) Overexpression of KLF8 increases migration and invasion towards CXCL12. The 10A-ik8 cells grown under U or I conditions were subject to Boyden chamber migration Assay (a) or Matrigel invasion assay (b). (C, D) Knockdown of KLF8 inhibits CXCR4-dependent migration and invasion towards CXCL12. The 231-K8ikd cells grown under U or I conditions with or without overexpression of CXCR4 (WT) or its ligand-binding defective mutant (dN20) were subject to Boyden chamber migration Assay (c) or Matrigel invasion assay (d). No detectable migration or invasion was observed towards serum-free medium in the absence of CXCL12. Inset, ectopic expression of CXCR4 and the dN20 mutant were verified by anti-HA western blotting.