Table 1. Associations between miR-16 and IKBKB expression levels and the clinicopathological characteristics of breast cancer patients.
| Variables | Cases (n) | miR-16 Expression (n) |
P value | IKBKB Expression (n) |
P value | ||
|---|---|---|---|---|---|---|---|
| Low | High | Low | High | ||||
| Age (years) | 0.129 | 0.060 | |||||
| <50 | 56 | 36 | 20 | 26 | 30 | ||
| ≥50 | 34 | 27 | 7 | 9 | 25 | ||
| Pathological classification | 0.275 | 0.351 | |||||
| Invasive ductal carcinoma | 59 | 44 | 15 | 20 | 39 | ||
| Invasive lobular carcinoma | 16 | 11 | 5 | 7 | 9 | ||
| Medullary carcinoma | 15 | 8 | 7 | 8 | 7 | ||
| Pathological grade * | 0.953 | 0.663 | |||||
| I | 8 | 6 | 2 | 3 | 5 | ||
| II | 37 | 28 | 9 | 11 | 26 | ||
| III | 14 | 10 | 4 | 6 | 8 | ||
| T staging | 0.021 | <0.001 | |||||
| T1+T2 | 65 | 41 | 24 | 34 | 31 | ||
| T3+T4 | 25 | 22 | 3 | 1 | 24 | ||
| Lymph node metastasis | 0.059 | <0.001 | |||||
| No | 43 | 26 | 17 | 27 | 16 | ||
| Yes | 47 | 37 | 10 | 8 | 39 | ||
| Distant metastasis | 0.537 | 0.100 | |||||
| No | 75 | 51 | 24 | 32 | 43 | ||
| Yes | 15 | 12 | 3 | 3 | 12 | ||
| Clinical staging | 0.711 | 0.008 | |||||
| I | 13 | 8 | 5 | 10 | 3 | ||
| II | 48 | 34 | 14 | 19 | 29 | ||
| III | 14 | 9 | 5 | 3 | 11 | ||
| IV | 15 | 12 | 3 | 3 | 12 | ||
*
The correlation between miR-16/IKBKB expression and pathological grade were only analyzed in 59 cases of Invasive ductal carcinoma patients.