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. 2016 Mar 17;7(17):23684–23699. doi: 10.18632/oncotarget.8152

Figure 3. Effect of escin Ia on invasion-related factors in MDA-MB-231 cells.

Figure 3

MDA-MB-231 cells were treated with escin Ia (2.5, 5, 10 μM) for 24 h, and the mRNA expressions of breast cancer metastasis suppressor 1 (BRMS1), E-cadherin, Keratin19, lysyl oxidase-like 2 (LOXL2), metal matrix proteinase 9 (MMP9), calcium release-activated calcium channel protein 1 (Orai1), stromal interaction molecule 1 (Stim1), transforming growth factor (TGF-β) and vascular endothelial growth factor (VEGF) were measured by using Q-PCR assay. Gene expressions were normalized to GAPDH. The data were expressed as the means ± S.E.M. of three independent experiments. *p < 0.05, **p < 0.01 vs. normal.