Table 4. The interaction of three miRNA polymorphisms with H.pylori infection status in the risk of gastric cancer/atrophic gastritis^a.

		let-7e rs8111742		miR-365b rs121224		miR-4795 rs1002765
		GA+GG	AA	CG+CC	GG	GA+GG	AA
AG vs CON (n=862 Vs. 862)
H.pylori
H.pylori(−)	Case/Control	332/574	25/47	278/503	79/118	295/534	62/87
	OR(95%CI)	1(Ref)	0.92(0.55-1.52)	1(Ref)	1.21(0.88-1.66)	1(Ref)	1.29(0.90-1.83)
H.pylori(+)	Case/Control	469/226	36/15	407/195	98/46	425/193	80/48
	OR(95%CI)	3.61(2.93-4.45)	4.14(2.23-7.67)	3.80(3.03-4.76)	3.84(2.63-5.61)	3.97(3.18-4.96)	3.14(2.12-4.63)
		Pinteraction=0.592		Pinteraction=0.488		Pinteraction=0.079
		interaction index=1.25		interaction index=0.84		interaction index=0.62
GC vs CON (n=724 Vs. 729)
H.pylori
H.pylori(−)	Case/Control	334/484	21/44	287/429	68/99	297/456	58/72
	OR(95%CI)	1(Ref)	0.69(0.40-1.18)	1(Ref)	1.02(0.73-1.44)	1(Ref)	1.23(0.85-1.79)
H.pylori(+)	Case/Control	332/190	37/11	310/162	59/39	324/163	45/38
	OR(95%CI)	2.55(2.03-3.20)	4.85(2.44-9.65)	2.88(2.26-3.67)	2.25(1.46-3.46)	3.04(2.39-3.86)	1.91(1.20-3.03)
		Pinteraction=0.024		Pinteraction=0.353		Pinteraction=0.031
		interaction index=2.75		interaction index=0.77		interaction index=0.51

Note:

^aP for interaction was used Logistic Regession adjusted by gender and age. CON:controls; AG: atrophic gastritis; GC:gastric cancer.