Table 1. Kinase domain mutations leading to acquired resistance.

Cell line	Observed mutation from this study	Variants observed by others	Disease observed in	Reported resistance phenotype	Reference
SUP-CR500-2	I1171S	I1171S	NPM-ALK ALCL	ASP-3026-R*	[39]
			EML4-ALK NSCLC	Crizotinib-R Alectinib-R	[38]
		I1171T	NPM-ALK ALCL	Crizotinib-R Ceritinib-R Alectinib-R AP26113-R ASP3026-R	[39, 46]
			EML4-ALK NSCLC	Crizotinib-R Ceritinib-S Alectinib-R	[36, 43–45, 47, 48]
		I1171N	NPM-ALK ALCL	Crizotinib-R Ceritinib-R Alectinib-R AP26113-R ASP3026-S	[39, 41, 42]
			EML4-ALK NSCLC	Alectinib-R	[38, 45]
			Neuroblastoma	Somatic	[10, 37, 70]
		I1171H	EML4-ALK NSCLC	Crizotinib-R	[36]
SUP-LR150	F1174L	F1174L	EML4-ALK NSCLC	Crizotinib-R Alectinib-S	[55, 57, 71]
			RANBP2-ALK IMT	Crizotinib-R	[56]
			Neuroblastoma	Somatic	[7–10, 37, 54, 72]
		F1174V	NPM-ALK ALCL	Crizotinib-S Ceritinib-S Alectinib-R AP26113-S ASP3026-R	[60]
			EML4-ALK NSCLC	Crizotinib-R Ceritinib-R	[43, 44, 47, 58]
			Neuroblastoma	Somatic	[7, 9, 10, 37]
		F1174C	NPM-ALK ALCL	Alectinib-R	[46]
			EML4-ALK NSCLC	Crizotinib-R Ceritinib-R	[36, 47]
			Neuroblastoma	Somatic	[7, 9, 10, 37]
		F1174I	NPM-ALK ALCL	Crizotinib-S Ceritnib-S Alectinib-S AP26113-S ASP3026-R	[39]
			Neuroblastoma	Somatic	[10, 37, 62]
		F1174S	Neuroblastoma	Somatic	[73]
DHL1-CR500	R1192P	R1192P	Neuroblastoma	Germline	[10]
		R1192Q	Uterine leiomyosarcoma		[74]
DHL1-LR150	T1151M	T1151M	Neuroblastoma	Germline	[8, 62]
		T1151R	Neuroblastoma	Germline	[75]
		T1151K	EML4-ALK NSCLC	Crizotinib-R	[36]
		1151Tins	EML4-ALK NSCLC	Crizotinib-R Ceritinib-R AP26113-R ASP3026-R	[25, 47, 58, 61]
DHL1-CR500-2	G1269A	G1269A	NPM-ALK ALCL	Crizotinib-R Ceritinib-S Alectinib-R AP26113-S ASP3026-R	[64]
			EML4-ALK NSCLC	Crizotinib-R Ceritinib-S Alectinib-R [64] Alectinib-S [48, 76] AP26113-S ASP3026-R	[47, 48, 58, 63, 64, 66, 76]
		G1269S	EML4-ALK NSCLC	Crizotinib-R	[36, 55]

Abbreviations: ALCL = Anaplastic Large Cell Lymphoma; NSCLC = Non-Small Cell Lung Cancer; IMT = Inflammatory Myofibroblastic Tumor; R = Resistant; S = Sensitive.

^*Seen by ultra-deep sequencing at low frequency.