Table 3. FL5.12 NPM-ALK mutant IC50s.
FL5.12 NPM-ALK | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WT | I1171S | F1174L | R1192P | T1151M | G1269A | ||||||||
IC50 | Fold Change | IC50 | Fold Change | IC50 | Fold Change | IC50 | Fold Change | IC50 | Fold Change | IC50 | Fold Change | ||
TKI | Crizotinib | 171.85 | 1 | 345.03 | 2.01 | 347.63 | 2.02 | 421.5 | 2.45 | 346.65 | 2.02 | 871.75 | 5.07 |
Ceritnib | 34.03 | 1 | 75.8 | 2.23 | 140.45 | 4.13 | 167.08 | 4.91 | 95.78 | 2.81 | 46.04 | 1.35 | |
Alectinib | 11.13 | 1 | 192.5 | 17.29 | 46.43 | 4.17 | 48.84 | 4.39 | 25.42 | 2.28 | 89.27 | 8.02 |