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. 2016 Mar 18;7(17):23715–23729. doi: 10.18632/oncotarget.8173

Table 3. FL5.12 NPM-ALK mutant IC50s.

FL5.12 NPM-ALK
WT I1171S F1174L R1192P T1151M G1269A
IC50 Fold Change IC50 Fold Change IC50 Fold Change IC50 Fold Change IC50 Fold Change IC50 Fold Change
TKI Crizotinib 171.85 1 345.03 2.01 347.63 2.02 421.5 2.45 346.65 2.02 871.75 5.07
Ceritnib 34.03 1 75.8 2.23 140.45 4.13 167.08 4.91 95.78 2.81 46.04 1.35
Alectinib 11.13 1 192.5 17.29 46.43 4.17 48.84 4.39 25.42 2.28 89.27 8.02