Table 4. FL5.12 EML4-ALK mutant IC50s.

		FL5.12 EML4-ALK
		WT		I1171S		F1174L		R1192P		T1151M		G1269A
		IC50	Fold Change	IC50	Fold Change	IC50	Fold Change	IC50	Fold Change	IC50	Fold Change	IC50	Fold Change
TKI	Crizotinib	70.59	1	260.38	3.7	68.14	0.97	86.27	1.25	89.07	1.27	395.2	5.62
	Ceritnib	9.6	1	64.69	6.79	16.86	1.76	16.96	1.79	24.24	2.53	14.57	1.52
	Alectinib	3.46	1	224.28	64.98	3.35	0.98	2.55	0.70	3.00	0.87	40.09	11.6
	AP26113	4.13	1	24.87	6.09	5.79	1.42	2.7	0.66	3.81	0.93	4.4	1.08
	ASP3026	42.21	1	245.13	5.83	110.97	2.63	90.59	2.11	105.73	2.51	71.79	1.71
	AZD3463	16.79	1	38.27	2.28	15.83	0.94	10.16	0.59	18.99	1.13	11.62	0.69