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. 2016 Mar 14;7(17):23740–23756. doi: 10.18632/oncotarget.8060

Figure 4. Cancer cell-secreted VEGF modulated by DEK regulates HUVEC tube formation and angiogenesis.

Figure 4

A. Tube formation assays were performed for HUVEC cells cultured in the conditioned medium from MCF-7 cells stably infected as in Figure 3A. B. Tube formation assays were performed for HUVEC cells cultured in the conditioned medium from MCF-7 cells stably transfected and treated as in Figure 3B. C. CAM assays were performed with conditioned medium from MCF-7 cells stably infected as in Figure 3A. D. CAM assays were performed with conditioned medium from MCF-7 cells stably transfected and treated as in Figure 3B. The image displayed is one of the representative results (A-D). Scale bar: 100 μm (A, B). All values shown are mean ± SD of triplicate measurements and have been repeated 3 times with similar results (A-D). *P < 0.05, **P < 0.01 versus empty vector or control shRNA plus empty vector. The raw data of tube formation and CAM was presented in Supplementary Table S2.