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. 2016 Mar 16;7(17):23757–23771. doi: 10.18632/oncotarget.8121

Figure 2. Upregulation of E2F8 correlates with progression and poor prognosis in breast cancer.

Figure 2

(A) Left panel: representative IHC analyses of E2F8 expression in normal breast tissue and breast cancer specimens of different clinical stages. Right panel: Statistical quantification of the mean optical density (MOD) of E2F8 staining between normal breast tissues and breast cancer specimens. *P < 0.05. (B) Kaplan-Meier analysis of overall survival curves for breast cancer patients with low E2F8 expression (E2F8-L; n = 95) versus high E2F8 expression (E2F8-H; n = 92) (n = 187; P < 0.001, log-rank test). (C and D) E2F8 expression also significantly correlated with overall survival in breast cancer patients with clinical stage 1 + 2 subgroup (n = 128; P = 0.001, log-rank test), or clinical stage 3 + 4 subgroup (n = 59; P = 0.039, log-rank test).