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. 2016 Mar 16;7(17):23785–23800. doi: 10.18632/oncotarget.8122

Figure 6. LL-37 and TRPV2 cooperate in cell cancer lines and breast tumors.

Figure 6

(A) Immunohistochemical analysis of breast tumors reveals coexpreussion of LL-37 and TRPV2. Left panel: representative example of sections from two breast carcinomas showing strong signals for both LL-37 and TRPV2 staining, or low immunoreactivity for either of them. Right panel displays the evaluation of 101 breast tumors, and revealing significant coexpression of LL-37 and TRPV2 (chi-square: p < 10−4). (B) Immunohistochemistry on the MCF7 cell line, revealing an increased signal for TRPV2 in cells with transgenic expression of hCAP18/LL-37. (C) RNA interference against TRPV2 decreases LL-37 induced cell migration of MCF7 (left panel) and MDA-MB-231 (right panel) cells.