Table 1. Clinicopathological information of ICC patients.

Case	WES	RNA-Seq	Gender	Age (yrs; at diagnosis)	HBV Ag	HCV Ag	Hepatolithiasis	CA19–9 (U/m)	Tumor Differentiation	Tumor size (cm)	TNM stage	Vital Status	Follow-up months
ICC3		Yes	M	60	No	No	No	9.8	M	2.5	T1N0M0	Alive	19
ICC4		Yes	F	71	Yes	No	No	7	M	3.9	T1N0M0	Alive	18
ICC5		Yes	M	48	No	No	No	625	P	8	T3N1M0	Alive	17
ICC6	Yes	Yes	M	65	No	No	No	1327	P	7.5	T3N1M0	Death	7
ICC8		Yes	M	66	No	No	No	ND	P	6	T1N0M0	Death	9
ICC10	Yes	Yes	M	63	No	No	No	ND	P	9.8	T1N0M0	Alive	13
ICC11		Yes	M	66	No	No	No	14.1	P	4.8	T2bN1M0	Alive	12
ICC14		Yes	F	69	No	No	Yes	17630	P	10.5	T3N1M0	Death	4
ICC15		Yes	F	58	No	No	No	12.5	P	4.2	T2aN0M0	Alive	10
ICC16	Yes	Yes	F	62	Yes	No	No	18	ND	2.7	T4N0M0	Alive	8
ICC19	Yes		F	63	Yes	No	No	ND	P	2.5	T3bN0M0	Death	8
ICC23	Yes		M	49	Yes	No	No	ND	P	2.2	T1N0M0	Alive	74
ICC25	Yes		M	64	No	No	No	310	P	2.2	T2N0M0	Death	52
ICC26	Yes		M	57	Yes	No	No	ND	P	3.4	T4N1M0	Alive	67
ICC29	Yes		M	70	No	No	No	15.3	ND	3.6	T1N0M0	Death	9
ICC30	Yes		M	78	No	No	No	86	M	8	T1N0M0	Death	20
ICC31	Yes		M	61	No	No	No	2297	P	5	T4N1M0	Alive	7

ND represents non-determined in the corresponding case. Tumor differentiation are poor- (P), moderate- (M) and well-differentiated (W). Follow-up months represent the months to death in case of deceased patients.