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. 2016 Mar 19;7(17):23961–23974. doi: 10.18632/oncotarget.8208

Figure 1. Secretome from radioresistant cells promotes survival of radiosensitive cells in NSCLC.

Figure 1

(A) Effects of CM derived from radioresistant A549 cells on survival of radiosensitive NCI-H460 cells in response to radiation were measured by a colony forming assay. The relative numbers of colonies of NCI-H460 cells are indicated in the graph. *p < 0.05 compared with irradiated cells treated with control media. (B) Effects of CM derived from other radioresistant cells, NCI-H358 and NCI-H292 cells, on survival of NCI-H460 cells in response to radiation were measured by a colony forming assay. *p < 0.05 compared with irradiated cells treated with control media. (C) Effects of CM derived from A549, NCI-H358, or NCI-H292 cells on radiation-induced apoptosis of NCI-H460 cells were analyzed by an Annexin V staining assay. The relative levels of Annexin V- and PI-positive populations of NCI-H460 cells are indicated in the graph. *p < 0.05 compared with non-irradiated cells; **p < 0.05 compared with irradiated cells treated with control media.