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. 2016 Mar 19;7(17):23961–23974. doi: 10.18632/oncotarget.8208

Figure 6. Inhibition of PAI-1-mediated intercellular communication decrease in vivo radioresistance and EMT in a xenograft mouse model.

Figure 6

(A) An experimental protocol to determine whether a PAI-1 inhibitor decreases in vivo radioresistance and EMT in a xenograft mouse model. (B) Effects of CM of A549 cells and a PAI-1 inhibitor on in vivo radioresistance in a xenograft mouse model. *p < 0.05 for tumor tissues from irradiated mice treated with CM versus tumor tissues from animals treated with radiation alone or those treated with radiation, CM, and tiplaxtinin. (C) In vivo effects of CM and a PAI-1 inhibitor on ERK1/2 phosphorylation, PARP cleavage, and expression of EMT-related proteins were evaluated by Western blotting.