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. 2016 Mar 14;7(17):23975–23987. doi: 10.18632/oncotarget.8073

Figure 1. Effects of SIRT1 expressed in cancer and host cells on tumor growth.

Figure 1

A. Scheme for allotransplantation of B16F10 stable cell lines into wild type (WT) and SIRT1-transgenic (TG) mice. Left and right panels show immunoblotting of SIRT1 in B16F10 cell lines and photographs of WT and SIRT1-TG littermates, respectively. B. Control and SIRT1-expressing B16F10 stable cell lines were implanted into the flanks of WT and TG mice. Tumors were excised (left) and weighed (right) on day 14 after transplantation. All results are shown as the mean ± s.e.m. (n=8; right). *, p < 0.05. C. TUNEL analysis and PCNA staining were performed in tumor tissue sections (left). Numbers of PCNA-positive cells per high-power field (HPF) at 400× magnification (means + s.d.; n=4) are shown (right). *, p < 0.05; scale bar, 100 μm.