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. 2016 Mar 14;7(17):23975–23987. doi: 10.18632/oncotarget.8073

Figure 4. Role of fibroblast SIRT1 in cancer cell proliferation.

Figure 4

Cancer cells (B16F10, SKOV3, and SNU840) and fibroblasts (MEF-1 and CCD18Lu) were transfected with plasmids A. or siRNAs B. as described in Figure 3. Cancer cells were cultured in a 1:1 (v/v) mixture of conditioned medium from fibroblasts and fresh medium. Cell growth was analyzed using MTT. Data (mean ± s.d.; n=4) are plotted as a function of incubation time. *, p < 0.05. P, +S, N, and -S denote the transfection with pcDNA, SIRT1 plasmid, non-targeting RNA, and SIRT1-targeting siRNA, respectively.