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. 2016 Mar 14;7(17):23975–23987. doi: 10.18632/oncotarget.8073

Figure 7. MMP3 acts as a growth factor for cancer cells.

Figure 7

A. Cancer cells (B16F10, SKOV3, or SNU840) cells were co-cultured with fibroblasts (MEF-1 or CCD18Lu) which were transfected with SIRT1. MMP3 inhibitor at the indicated concentrations was administered into the co-culture media. B. Conditioned media were collected from fibroblasts transfected with si-SIRT1 (80 nM). Cancer cells were cultured in a 1:1 (v/v) mixture of the conditioned medium and fresh medium, and treated with recombinant human MMP3 (rhMMP3) at the indicated concentrations. Cancer cell growth was estimated using MTT. Data (mean ± s.d.; n=4-6) are plotted as a function of incubation time. *, p < 0.05.