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. 2016 Mar 19;7(17):24005–24017. doi: 10.18632/oncotarget.8209

Figure 5.

Figure 5

(A) Representative image and quantification of hepatospheres in MIHA cells with HBx-Δ14 and HBx-Δ35 stably overexpressed, in the absence or presence of FXR inhibitor, Z-guggulsterone (Z-gugg; 25 μM). Scale bar = 100 μm. *compared to EV with ***p < 0.001, **p < 0.01, *p < 0.05. #compared to DMSO with ##p < 0.01, #p < 0.05. (B) Representative image and quantification of number of cells that migrated in MIHA cells with HBx-Δ14 and HBx-Δ35 stably overexpressed in the absence or presence of FXR inhibitor, Z-guggulsterone (Z-gugg; 25 μM). Scale bar = 100 μm. *compared to EV with ***p < 0.001, *p < 0.05. #compared to DMSO with ###p < 0.001, #p < 0.05. (C) Cartoon summary of the role of C-terminal truncated HBx variants, in particular HBx-Δ14 and HBx-Δ35, in promoting cancer and stem cell-like features in vitro in HCC.