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. 2016 Mar 21;7(17):24483–24494. doi: 10.18632/oncotarget.8231

Figure 5. The phosphorylation of TOPK at Y74, Y272 by Src enhances the activity of TOPK.

Figure 5

A. JB6/ WT and JB6/ FF cells were treated with EGF (20 ng/ml; 15 min), and the samples were analyzed by Western blot. B. Src+/+ and Src−/− MEFs were treated with EGF (20 ng/ml; 15 min), and analyzed by Western blot. SW480 C. HCT15 D. and HCT116 E. cells were treated with Dasatinib for 24 h in a dose-dependent manner. Then Histones were isolated, resolved by SDS-PAGE and analyzed by Western blot, respectively. Data are representatives of results from triplicate experiments.