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. 2016 Mar 22;7(17):24734–24743. doi: 10.18632/oncotarget.8270

Figure 4. Role of miR-124-3p in glucagon release through iGluR2/3 targeting.

Figure 4

Lenti-virus particles are used to overexpress or inhibit miR-124 expression in islets; and lenti-virus particles containing shRNA are used to suppress the expression of iGluR2/3 expression. A. relative levels of miR-124 in islets treated with pre- or anti-miR-124 (n=3). B. Relative levels of iGluR2/3 mRNA in islets treated with shRNAs (n=3). C and D. The expression of iGluR2 (C) and iGluR3 (D) in isolated islets transfected with shRNA or pre/anti-miR-124-3p mediated through lentiviral particles (n=5). E-G. Glutamate and kainite-stimulated glucagon release from islets transfected with iGluR2/3 shRNAs or pre/anti-miR-124-3p (n=5). ** indicates p<0.01.